When do you check peak and trough for gentamicin?

When do you check peak and trough for gentamicin?

Both peak and trough concentrations should be monitored. The trough sample is drawn immediately prior to the next dose. Peak samples should be drawn 45 to 60 minutes after an IM injection, 30 minutes after the end of a 30-minute IV infusion, or immediately after a 60-minute IV infusion.

Does gentamicin need monitoring?

Gentamicin can cause serious dose-related side effects including nephrotoxicity and irreversible hearing loss, so it is important to ensure patients receive the correct dose and are monitored regularly.

How do you monitor gentamicin?

Therapeutic drug monitoring Serum-gentamicin concentration should be measured after 3 or 4 doses, then at least every 3 days and after a dose change (more frequently in renal impairment). For once-daily dose regimen, consult local guidelines on monitoring serum-gentamicin concentration.

Why do you draw blood before and after gentamicin?

This test is used to monitor the level of the prescribed aminoglycoside antibiotic in the blood. Testing is used to ensure that the level of the drug in the blood is sufficient to treat the infection but not so high as to increase the risk of side effects.

When do you use gentamicin trough?

A gentamicin trough level should be obtained within 1 hour of the dose: Obtain level prior to the administration of the 2nd dose. If impaired renal function is a concern, a level should be obtained before the 2nd dose. An acceptable trough is < 2 mcg/ml, with an optimal target ≤ 1.0.

Does IM gentamicin need to be diluted?

Injection, USP – 80 mg/2 mL – (40 mg/mL as Gentamicin) FOR INTRAVENOUS INFUSION OR INTRAMUSCULAR INJECTION – CAUTION: MUST BE DILUTED FOR INTRAVENOUS USE.

What should be monitored when taking gentamicin?

Patients who require treatment with gentamicin often require monitoring, which includes peak and trough levels. Peak levels are typically evaluated 30 minutes after completion of the infusion. Trough levels should be drawn immediately before the dose is administered.

Why do you monitor trough concentrations for gentamicin?

The initial gentamicin dosage regimen was 4 mg/kg every 24 hours, and the purpose of predicting 24-hour trough concentrations of 1 mg/l or less was to distinguish between babies in whom the second dose of gentamicin could be administered safely at 24 hours, and those in whom the dosing interval should be extended …

What blood tests should be monitored when administering gentamicin?

Therapeutic Drug Monitoring (TDM) TDM is required for patients on aminoglycosides (e.g. gentamicin, amikacin, tobramycin) and glycopeptides (e.g.vancomycin). Serum concentration monitoring aims to avoid both excessive and sub-therapeutic concentration thereby preventing toxicity and ensuring efficacy.

Can gentamicin be given IM?

Gentamicin injection comes as a liquid to be injected intravenously (into a vein) or intramuscularly (into a muscle). When gentamicin is injected intravenously, it is usually infused (injected slowly) over a period of 30 minutes to 2 hours once every 6 or 8 hours.

Are post dose (peak) levels required for gentamicin?

 Post dose (peak) levels are not required.  When the first dose of gentamicin has been given in the evening or night, the level should be taken by 1500hr the following day if this falls within 18- 24 hour window and sent for analysis immediately.

Is gentamicin TDM required for aminoglycosides?

Gentamicin TDM is required for patients on aminoglycosides (e.g. gentamicin, amikacin, tobramycin) and glycopeptides (e.g.vancomycin). Serum concentration monitoring aims to avoid both excessive and sub-therapeutic concentration thereby preventing toxicity and ensuring efficacy.

How often should I monitor my gentamicin levels?

 Provided renal function is stable, and continued gentamicin administration is required, monitor gentamicin levels twice weekly i.e. after the 1st and 3rd or 4th dose. Trough level 1 – 2mg/L Provided renal function is unchanged increase the dosing interval to 36 – 48 hours.

What is the minimum dose of gentamicin to improve renal function?

Provided renal function is stable, and continued gentamicin administration is required, monitor gentamicin levels twice weekly i.e. after the 1st and 3rd or 4th dose. Trough level 1 – 2mg/L Provided renal function is unchanged increase the dosing interval to 36 – 48 hours. Trough level > 2mg/L Omit next dose, re-assay in 24hours.