What is CTX in osteoporosis?
CTX — which stands for C-terminal cross-linked telopeptide — is an indicator of bone turnover. Turnover refers to the remodeling process by which bone is continually broken down (resorption) and built up (formation). High bone turnover rates increase the risk for osteoporosis.
What does high CTX mean?
Elevated levels of beta-C-terminal telopeptide (CTx) indicate increased bone resorption. Increased levels are associated with osteoporosis, osteopenia, Paget disease, hyperthyroidism, and hyperparathyroidism.
What is a good CTX level?
Information on the serum CTX Test
| CTX Value | Risk for ONJ |
|---|---|
| 300 to600 pg/ml (normal) | none |
| 150 to 299 pg/ml | none to minimal |
| 101 to 149 pg/ml | moderate |
| Less than 100 pg/ml | high |
Is low CTX good?
Actual normal values are usually well over 300 pg/mL and are most commonly 400 pg/mL to 550 pg/mL in patients not taking bisphosphonates. Lower values represent varying degrees of suppression of normal bone turnover, sometimes also called bone remodeling or bone renewal.”
How is CTX introduced to a patient?
Te bacterium Vibrio cholerae, which contains the cholera toxin (CTX), is transmissible by the fecal-oral route because the bacteria is still present in a person’s feces when they defecate.
What is CTX and NTX?
The NTX test is based on an antibody against the N-terminal of collagen, including the cross-linking region; CTX is based on an antibody to an octapeptide at the C-terminal end.
What are the markers of bone degradation?
A summary list of bone resorption markers is as follows:
- Urinary hydroxyproline.
- Urinary total pyridinoline (PYD)
- Urinary free deoxypyridinoline (DPD)
- Urinary collagen type 1 cross-linked N-telopeptide (NTX)
- Urinary or serum collagen type 1 cross-linked C-telopeptide (CTX)
- Bone sialoprotein (BSP)
What is CTX beta Crosslaps?
Beta-CTx is released into the bloodstream during bone resorption and serves as a specific marker for the degradation of mature type I collagen. Elevated serum concentrations of beta-CTx have been reported in patients with increased bone resorption.
Is CTx a fasting blood test?
Test Details A minimum of 12 hours fasting is required.
How is CTx introduced to a patient?
Is CTX a fasting blood test?
What is the process of bone resorption?
Bone resorption is the process by which the bones are absorbed and broken down by the body. Osteoclast cells are responsible for the breakdown of bone minerals thus releasing calcium and phosphorous into the bloodstream. This occurs when the body has insufficient calcium from an individual’s diet.
What is serum CTX in bone resorption?
Serum CTX: a new marker of bone resorption that shows treatment effect more often than other markers because of low coefficient of variability and large changes with bisphosphonate therapy Calcif Tissue Int. 2000 Feb;66(2):100-3.doi: 10.1007/pl00005830.
What is a CTX blood test for osteoporosis?
The CTx blood test is designed to measure the amount of bone materials that have degraded into a person’s bloodstream. By detecting the collagen of the bone, it is most commonly used to detect the presence of osteoporosis.
What is the CTX test used for?
Clinical Significance Collagen Type I C-Telopeptide (CTx) – CTx is useful to assess bone resorption in patients with metabolic bone disease. The test is also useful in monitoring therapy to slow or halt osteoporotic bone loss.
Is CTX a useful marker in monitoring patients on antiresorptive therapy?
However, the utility of this and other markers in monitoring patients on antiresorptive therapy depends on ho … Serum CTX: a new marker of bone resorption that shows treatment effect more often than other markers because of low coefficient of variability and large changes with bisphosphonate therapy