What is an oligodendroglioma?
Oligodendrogliomas are brain tumors arising from oligodendrocytes, a type of cell that makes up the supportive (glial) tissue of the brain. They can be low-grade (grade II) or high-grade (grade III, also called anaplastic). While they can be found anywhere within the cerebral hemisphere, they are most common in the frontal and temporal lobes.
What is the prognosis of oligodendroglioma (Grade II) cancer?
For patients with the slower-growing oligodendroglioma (grade II), surgery is often sufficient to remain tumor-free for many years. However, patients will continue to be monitored for both tumor recurrence and progression to a higher grade tumor.
Can histopathology alone diagnose oligodendroglioma?
For nearly a century, the diagnosis and grading of oligodendrogliomas and oligoastrocytomas has been based on histopathology alone. Roughly 20 years ago, the first glioma-associated molecular signature was found with complete chromosome 1p and 19q codeletion being particularly common in histological …
What is the who grade of anaplastic oligodendroglioma?
Histologically, oligodendrogliomas most often correspond to WHO grade II, whereas the anaplastic oligodendrogliomas are WHO grade III. Most oligodendendroglial tumors are sporadic neoplasms.
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Oligodendroglioma is a rare tumor that occurs in the brain. It belongs to a group of brain tumors called gliomas. Gliomas are primary tumors. This means they have originated in the brain rather than spreading from elsewhere in the body. Around 3% of all brain tumors are oligodendrogliomas.
What are the treatment options for oligodendroglioma?
The first treatment for an oligodendroglioma is surgery, if possible. The goal of surgery is to obtain tissue to determine the tumor type and to remove as much tumor as possible without causing more symptoms for the person. Treatments after surgery may include radiation, chemotherapy, or clinical trials.
What do oligodendrogliomas look like on an MRI?
What do oligodendrogliomas look like on an MRI? Oligodendrogliomas usually appear as a single tumor with well-defined borders. The tumor may enhance with contrast and is most often seen in anaplastic oligodendrogliomas. Oligodendrogliomas tend to have some swelling around them.
How common are oligodendroglioma brain tumors?
Around 3% of all brain tumors are oligodendrogliomas. The tumors can be fast or slow growing. They are more commonly diagnosed in adults, though young children can also be affected. In rare cases, the tumors can spread through the central nervous system via the fluid around your brain and spinal cord.