What does GH1 gene do?
The GH1 gene provides instructions for making the growth hormone protein. Growth hormone is produced in the growth-stimulating somatotropic cells of the pituitary gland, which is located at the base of the brain. Growth hormone is necessary for the normal growth of the body’s bones and tissues.
What type of receptor is the growth hormone receptor?
I cytokine receptor family
The growth hormone receptor (GHR) is a member of the class I cytokine receptor family, which includes more than 30 receptors such as the prolactin receptor (PRLR), erythropoietin receptor (EPOR), thrombopoietin receptor (TPOR), granulocyte-macrophage colony-stimulating factor receptor, interleukin-3 receptor.
What is Ishgh?
Overview. Human growth hormone (hGH) is a naturally occurring hormone produced by the pituitary gland. It’s important for growth, cell regeneration, and cell reproduction. HGH helps to maintain, build, and repair healthy tissue in the brain and other organs.
Is GH1 a protein?
GH1 (Growth Hormone 1) is a Protein Coding gene. Diseases associated with GH1 include Isolated Growth Hormone Deficiency, Type Ib and Kowarski Syndrome.
Where is growth hormone receptor?
Growth hormone receptors (GHRs) have been found on the cell surfaces of many tissues throughout the body, including liver, muscle, adipose, and kidney, and in early embryonic and fetal tissue.
What is an isoform of the human growth hormone receptor used for?
“A short isoform of the human growth hormone receptor functions as a dominant negative inhibitor of the full-length receptor and generates large amounts of binding protein.” Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
What is the pathophysiology of growth hormone deficiency?
Disease description An autosomal recessive deficiency of growth hormone leading to short stature. Patients have low but detectable levels of growth hormone, significantly retarded bone age, and a positive response and immunologic tolerance to growth hormone therapy.
What are the other names for pituitary growth hormone?
Available under the names Nutropin or Protropin (Genentech), Norditropin (Novo Nordisk), Genotropin (Pharmacia Upjohn), Humatrope (Eli Lilly) and Saizen or Serostim (Serono). Used for the treatment of growth hormone deficiency and for Turner’s syndrome. More… More… “Human pituitary growth hormone. XIX. The primary structure of the hormone.”
What is the function of the soluble form of growth hormone?
The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling.