What does Esat 6 do?
ESAT-6, an abundantly secreted protein of Mycobacterium tuberculosis (M. tuberculosis) is an important virulence factor, inactivation of which leads to reduced virulence of M. tuberculosis.
Is Mycobacterium tuberculosis complex curable?
Treatment for M. tuberculosis includes an extended regimen with pyrazinamide, isoniazid, ethambutol, and rifampicin (if not resistant).
What is MB tuberculosis?
Mycobacterium tuberculosis (M. tb) is a species of pathogenic bacteria in the family Mycobacteriaceae and the causative agent of tuberculosis. First discovered in 1882 by Robert Koch, M. tuberculosis has an unusual, waxy coating on its cell surface primarily due to the presence of mycolic acid.
How many bacterial secretion systems are there?
Bacterial virulence factors are delivered either in the extracellular environment or directly into host cells. Most Gram-negative CF pathogens possess one or more specialized secretion systems to accomplish this task. Eight different secretion systems have been identified (Figure 1).
What does IGRA stand for?
The tuberculosis (TB) blood test, also called an Interferon Gamma Release Assay or IGRA, is a way to find out if you have TB germs in your body. The TB blood test can be done instead of a TB skin test (Mantoux). There are two kinds of TB blood tests: QuantiFERON®-TB.
What are the characteristics of Mycobacterium tuberculosis?
M. tuberculosis is a small, rod-shaped, strictly aerobic, acid-fast bacillus 1 . Like other mycobacteria, it is slow growing, resulting in more gradual development of disease when compared with other bacterial infections. Acid-fast bacilli are bacilli, which once stained, resist discoloration by acid and alcohol.
What is the function of the M tuberculosis ESX-1 secretion system?
Overall, the M. tuberculosisESX-1 secretion system appears to be a specialized system for the deployment of host membrane-targeting proteins, whose primary function is to interrupt key steps in innate immune mechanisms against pathogens.
Where is the ESPC in Mycobacterium tuberculosis?
(2017) EspC forms a filamentous structure in the cell envelope of Mycobacterium tuberculosis and impacts ESX-1 secretion. Mol Microbiol 103(1):26–38. . (2017) Discovery of the type VII ESX-1 secretion needle?
Is MTB ESX-1 secretion linked to virulence and hemolysis?
Fig. 1. Mtb ESX-1 secretion is linked to virulence and hemolysis. ( A) Bacterial growth in the J774 macrophage cell line as assessed by intracellular bacterial fluorescence. n = 12 fields per condition. * P < 0.05, two-way ANOVA with Dunnett’s test.
What is the role of ESAT-6 in tuberculosis (TB)?
(2011) Early secreted antigen ESAT-6 of Mycobacterium tuberculosis promotes protective T helper 17 cell responses in a toll-like receptor-2-dependent manner. PLoS Pathog 7(11):e1002378. . (September 21, 2016) ESAT-6 drives MMP-10 gene expression and secretion in tuberculosis. Am J Respir Cell Mol Biol doi:10.1165/rcmb.2016-0162OC. .