What does bi exponential mean?
(mathematics) Having two exponents.
What is Biexponential analysis?
Analysis Mode Settings provides a mechanism for fine-tuning specific aspects of your data. The Analysis Mode is set to biexponential by default (Automatic). Biexponential view is particularly useful when looking at compensated data that contains a significant number of events with negative fluorescence values.
What is the concentration of steady state?
Steady-state concentration (Css) occurs when the amount of a drug being absorbed is the same amount that’s being cleared from the body when the drug is given continuously or repeatedly. Steady-state concentration is the time during which the concentration of the drug in the body stays consistent.
What is a biexponential fit?
A biexponential equation/function/curve/model/distribution is the sum of two exponential ones. In specific, a biexponential model has the form. Biexponential time-series models commonly find use in pharmacokinetics.
What is Biexponential transformation?
Biexponential scaling helps visualize data that is compressed against the low x- and y- axes. Specifically, they address the problem of how to visualize high dynamic range data that contains both negative and positive values. For a more general overview on transforms, go here.
What is MRT PK?
When I first began learning about pharmacokinetics, I was often confused by the mean residence time (MRT) parameter. The MRT is calculated by summing the total time in the body and dividing by the number of molecules, which is turns out to be 85.6 minutes.
What is VSS in pharmacokinetics?
Pharmacokinetics – Concepts and Applications. Contributor © Minh Vo. C- Steady-state volume of distribution (Vss) Steady state volume of distribution (Vss) reflects the actual blood and tissue volume into which a drug is distributed and the relative binding of drug to protein in these spaces.
What is peak plasma level?
Cmax is the highest inhibitor concentration reached in the blood in vivo and is an approximation of the inhibitor concentration (I) at the enzymes in the liver. From: Drug-Like Properties (Second Edition), 2016.
What is Biexponential axis?
The biexponential scale is a combination of linear and log scaling on a single axis using an arcsine function as its backbone. The “logicle” implementation of biexponential was implemented in many popular software packages like FACSDiva and FlowJo. Other types of biexponential scaling exist, including Hyperlog.
What is t1 2 in pharmacology?
Half-life (t1/2) refers to the time required for plasma concentration of a drug to decrease by 50%. t1/2 is dependent on the rate constant (k), which is related to Vd & clearance (CL).