What causes Steven Johnsons Syndrome?

What causes Steven Johnsons Syndrome?

Stevens-Johnson syndrome is usually caused by an unpredictable adverse reaction to certain medications. It can also sometimes be caused by an infection. The syndrome often begins with flu-like symptoms, followed by a red or purple rash that spreads and forms blisters. The affected skin eventually dies and peels off.

What does early Steven Johnson Syndrome look like?

The first symptoms of SJS/TEN often include fever and flu-like symptoms (such as general ill feeling, body aches, and cough). Within about 1 to 3 days, a red or purplish rash forms, and then the skin begins to blister and peel, leading to “raw” areas of skin that are painful.

Can you get Stevens-Johnson syndrome twice?

The incidence of recurrence was 4.2 per 1000 person-years, which resulted from two episodes. One recurrence occurred in a patient with mycoplasma-associated SJS and the second case after inadvertent re-exposure to the inciting medication. This study found recurrence of SJS/TEN in adults to be uncommon.

Is Steven Johnson Syndrome autoimmune?

Stevens-Johnson syndrome, named after the two doctors who first described the disease in 1922, is an autoimmune disorder that manifests as a painful rash on the skin, mucous membranes, and genitals. The disease is often caused by an allergic reaction to certain medications.

How long does Steven Johnson Syndrome last?

If your case of SJS is caused by a drug, symptoms appear about one to three weeks after you start taking medication. The flu-like illness (fever, cough and headache, skin pain) is followed first by a rash and then peeling. In the case of TEN, some people even lose hair and nails.

How long does it take to recover from Steven Johnson Syndrome?

It can take weeks to months to recover. A more severe form of the condition is called toxic epidermal necrolysis (TEN). It involves more than 30% of the skin surface and extensive damage to the mucous membranes.

What is Stevens-Johnson syndrome?

Open pop-up dialog box. Close. Stevens-Johnson syndrome. Stevens-Johnson syndrome. Stevens-Johnson syndrome is a serious adverse reaction of the skin and mucous membranes. Signs and symptoms include blisters, rash and skin pain. Stevens-Johnson syndrome (SJS) is a rare, serious disorder of the skin and mucous membranes.

Is Lyell’s syndrome the same as Stevens-Johnson syndrome?

Yes. It is also known as Lyell’s syndrome, Stevens-Johnson syndrome/toxic epidermal necrolysis, and Stevens-Johnson syndrome toxic epidermal necrolysis spectrum. Depending on the cause, it might be called drug-induced Stevens-Johnson syndrome or mycoplasma-induced Stevens-Johnson syndrome.

What are Stevens-Johnson syndrome and toxic epidermal necrolysis (TEN)?

Stevens-Johnson syndrome (SJS) Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious skin conditions that cause skin to develop rashes, blisters, and then peel. Mucus membranes, including the eyes, vagina, and mouth, are also affected. People who get this condition are usually admitted to burn units in hospitals.

What drugs cause Stevens-Johnson syndrome?

Medications most likely to cause Stevens-Johnson syndrome include: Antibacterial sulfa drugs. Anti-epileptic drugs, including phenytoin (Dilantin®), carbamazepine (Tegretol®), lamotrigine (Lamictal®), and phenobarbital (Luminal®).