Is asgpr a glycoprotein?

The ASGPR, itself a glycoprotein, affects the binding and endocytosis of serum glycoproteins for disposal by the liver. It is a well-conserved protein except for differences in the number of subunits according to species: There are two in humans—H1 and H2.

What is the function of asialoglycoprotein receptor?

The human asialoglycoprotein receptor (ASGP-R), also called hepatic lectin, is a C-type (calcium dependent) lectin of hepatocytes that recognizes desialylated glycoproteins for endocytosis and lysosomal degradation. It has been largely studied in recent years [1–10] due to its possible role in a wide range of practical applications in human health.

What is the stoichiometry of ASGP-R?

The functional ASGP-R is a hetero-oligomer, that comprises of several subunits of two different kinds (H1 and H2), which are highly homologous. Its stoichiometry is still unknown.

What is the prevalence of anti ASGPRs?

Anti-ASGPRs are expressed in up to 88% of patients with AIH but are also present in other liver diseases such as PBC, alcoholic liver disease, and viral hepatitis [64,69].