Can LCH affect teeth?

Can LCH affect teeth?

Patients with bone LCH most often present localized pain and swelling of the affected area, sometimes with concurrent fever and the most commonly affected bones are the skull and the jawbone. In the oral region reported symptoms are gingivitis, periodontitis, tooth rotation or loss and malocclusion [7].

What are the symptoms of histiocytosis?

The first sign of histiocytosis is often a rash on the scalp, similar to cradle cap. There may be a pain in a bone, discharge from the ear, loss of appetite and fever. Sometimes the stomach is swollen and painful.

Is histiocytosis X an autoimmune disease?

Langerhans cell histiocytosis historically was thought of as a cancer-like condition, but more recently researchers have begun to consider it an autoimmune phenomenon in which immune cells begin to overproduce and attack the body instead of fighting infection.

What is an eosinophilic granuloma?

Eosinophilic granuloma (EG) is a rare, benign tumorlike disorder characterized by clonal proliferation of antigen-presenting mononuclear cells of dendritic origin known as Langerhans cells. It is the most common variant of Langerhans-cell histiocytosis (LCH).

How serious is eosinophilic granuloma?

Complications. There are possible complications from eosinophilic granuloma. While it does not occur in all cases, eosinophilic granuloma can spread to other bones or even the lymph nodes. Large tumors or tumors that press between bones may lead to bone fracture.

Will eosinophilic granuloma go away on its own?

In many cases, the lesion will spontaneously vanish over time. However, if the itching it causes persists, an affected cat may keep scratching at it, thereby opening it and subjecting the lesion to secondary infection.

What is a Birbeck granule?

The Birbeck granule is a rod-shaped bilaminar disk with an internal zipper-like pattern of striations, often with a bulbous dilatation at one end, like a tennis racquet. The granules are found wherever Langerhans cells are seen in the body but are not unique to Langerhans cells and have been described in other cells ( Fig. 19.15 ).

Which immunohistochemical markers are used to detect Birbeck granules in LCH?

Langerin (CD207) is a relatively new immunohistochemical marker that may serve as a surrogate indicator for the presence of Birbeck granules in LCH histiocytes.[11,13] In this case, S-100, CD-68 and CD1a immunostaining were positive which were confirmatory for LCH.

What is the prevalence of Langerhans cell histiocytosis?

INTRODUCTION Langerhans cell histiocytosis (LCH) is a rare disease characterized by proliferation, infiltration and accumulation of a specific histiocyte known as the Langerhans cell. The incidence of LCH is reported to be 3–5 per million in children but rare in adults.

What is the most common cause of osteonecrosis of the jaw?

In addition to the most common cause, medication related osteonecrosis of the jaw (MRONJ), one must consider a number of other causes, such as histiocytosis. Langerhans cell histiocytosis (LCH) is a histiocytic disorder with a large spectrum of clinical manifestations and with possible involvement of a variety of organs.