What are the 4 Starling forces?
The four Starling’s forces are:
- hydrostatic pressure in the capillary (Pc)
- hydrostatic pressure in the interstitium (Pi)
- oncotic pressure in the capillary (pc )
- oncotic pressure in the interstitium (pi )
What are the Starling forces in the glomerulus?
Glomerular filtration depends on the same opposing forces that produce the exchange of fluids in every capillary in our body: these are hydrostatic pressure and oncotic pressure and together they are known as Starling’s forces.
What are Starling forces physiology?
Starling forces describe the movement of fluids between the vasculature and interstitial spaces. Fluid movement is determined by the balance of hydrostatic and osmotic pressure gradients 1.
What Starling force causes edema?
Causes of edema by Starling forces: ↑ Capillary hydrostatic fluid pressure (e.g., heart failure) ↓ Plasma oncotic pressure (e.g., protein loss in nephrotic syndrome.
Why are Starling forces important?
Starling forces control the net flow of fluid across the alveolar membrane and are proportional to the permeability and surface area of the alveolar membrane, as well as the balance between hydrostatic and oncotic pressures of both the capillaries and alveoli.
What is the Starling equilibrium?
Starling pointed out over a century ago that under normal conditions, a state of near-equilibrium exists at the capillary membrane. That is, the amount of fluid filtering outward from the arterial ends of cap-illaries equals almost exactly the fluid returned to the circulation by absorption.
How do Starling forces affect GFR?
The net filtration pressure is determined by the balance of the Starling forces (the hydrostatic pressure and the oncotic pressure within the glomerular capillaries and Bowman’s capsule). An increase in renal arterial pressure (or renal blood flow) causes an increase in GFR.
What causes high pressure in glomerular capillaries?
In hypertension the glomerular capillary pressure tends to increase because the reduction in afferent arteriolar resistance is greater than the reduction in efferent resistance.
What are the 4 Starling forces involved in exchange between plasma in capillaries and the ECF?
There are three mechanisms that facilitate capillary exchange: diffusion, transcytosis and bulk flow. The net filtration pressure is the balance of the four Starling forces and determines the net flow of fluid across the capillary membrane.
When calculating Starling forces which force is responsible for pushing fluid out of the capillaries and into the interstitial fluid?
Hydrostatic pressure is a force generated by the pressure of fluid on the capillary walls either by the blood plasma or interstitial fluid. The net filtration pressure is the balance of the four Starling forces and determines the net flow of fluid across the capillary membrane.
What is the impact of congestive heart failure on Frank Starling law?
In heart failure, the Frank–Starling curve is moved down and flattened due to reduced inotropy, so that more venous return and hence preload is required to increase stroke volume. As venous return and preload rise, myocyte stretching occurs that increases sarcomere length.
Which of the starling’s forces moves fluid from blood to interstitial fluid and is increased when blood pressure increases?
The force of hydrostatic pressure means that as blood moves along the capillary, fluid moves out through its pores and into the interstitial space. …