Why does atractyloside stop ATP synthesis?
ATR binds competitively to the translocase competitive up to a concentration of 5 mmol while CATR binds in a non-competitive manner. As a result, the exchange of ADP and ATP is no longer carried out and the cell dies due to lack of energy.
What is the effect of atractyloside?
Atractyloside is a reagent that inhibits oxidative phosphorylation in mitochondria by preventing the translocation of adenine nucleotides, such as ATP, across the mitochondrial membrane.
How does atractyloside inhibit oxidative phosphorylation?
Atractyloside is an inhibitor of the adenine nucleotide translocator (ANT). It is an extremely toxic glycoside that inhibits oxidative phosphorylation by blocking the transfer of adenosine nucleotides through the mitochondrial membrane.
What is atractyloside target?
Atractyloside targets cancer-associated fibroblasts and inhibits the metastasis of colon cancer.
What is the effect of Atractyloside on electron transport and ATP formation by the respiratory chain?
What is the effect of each of the following inhibitors on electron transport and ATP formation by the respiratory chain? Atractyloside blocks electron-transport and ATP synthesis by inhibiting the exchange of ATP and ADP across the inner mitochondrial membrane.
How does Atractyloside effect mitochondrial respiration?
Atractyloside (ATR) is widely used as a specific inhibitor of mitochondrial adenine nucleotide translocase and it is also a potent nephrotoxin that selectively injures the proximal tubule in vivo. 2,4-Dinitrophenol (5 mM), which stimulated respiration in control mitochondria, failed to do this in the presence of ATR.
How does atractyloside affect mitochondrial respiration?
What is the effect of atractyloside on electron transport and ATP formation by the respiratory chain?
How does atractyloside effect mitochondrial respiration?
How does Atractyloside affect mitochondrial respiration?
Does Atractyloside affect electron transport?
Atractyloside blocks electron-transport and ATP synthesis by inhibiting the exchange of ATP and ADP across the inner mitochondrial membrane. O2 falls rapidly because the system is uncoupled and does not require ATP synthesis to lower the proton-motive force.
Is Atractyloside an Uncoupler?
Background and Aim: Atractyloside (ATR), a mitochondrial uncoupler, is known for its specific inhibition of mitochondrial oxidative phosphorylation.