Which cells express CXCR3?

Which cells express CXCR3?

CXCR3 (GPR9/CD183) is an interferon-inducible chemokine receptor expressed on various cell types, but preferentially monocytes, Th1 T cells, CD8 T cells, NKT cells, NK cells, dendritic cells, and some cancer cells (19–21).

Is CCR7 on T cells?

We find that CCR7 is expressed on the vast majority of peripheral blood T cells, including most cells that express adhesion molecules (cutaneous lymphocyte Ag alpha(4)beta(7) integrin) required for homing to nonlymphoid tissues.

What is an effector T cell?

The Effector T cell describes a group of cells that includes several T cell types that actively respond to a stimulus, such as co-stimulation. It includes CD4+, CD8+, Treg cells.

What does CCR7 stand for?

C-C chemokine receptor type 7
C-C chemokine receptor type 7 is a protein that in humans is encoded by the CCR7 gene.

Do T cells express CXCR5?

CXCR5 is expressed on a majority of memory CD4 T cells in the follicles of inflamed tonsils. Reciprocally, B cells activated by antigen in the follicles upregulate CCR7 and move toward the T-cell zone.

Where is CXCR5 found?

CXCR5 is detected on all peripheral blood and tonsillar B cells but only on a fraction of cord blood and bone marrow B cells (Forster et al., 1994). CXCR5 is expressed by a small subset of peripheral blood CD4+ (14%) and CD8+ (2%) T cells with a memory phenotype.

What is the function of CXCR3 in T cells?

In addition to a potential role during primary responses, CXCR3 expression by T cells in LNs may be important for the induction of T cell memory. CXCR3+ cells make up between 60–90% of CD8+ memory T cells [73, 74] and 40% of CD4+ memory T cells [75, 76].

Is CXCR3 a chemokine receptor?

Abstract CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells following activation and preferentially remains highly expressed on Th1-type CD4+ T cells and effector CD8+ T cells.

What is cxcr3-dependent T cell recruitment?

This has been observed in the context of CXCR3-dependent inflammation whereby CXCR3-dependent T cell recruitment permits the entry of CXCR3 negative and Cxcr3−/− T cells into immune privileged sites [26, 38].

Is CXCR3 a reliable marker for T memory responses?

CXCR3 expression has been proposed as a reliable marker for T memory responses, as viral recall responses for both CD8 + and CD4 + T cells are largely restricted to CXCR3 + cells [74], [76].