What is a paired pulse ratio?
It has been reported that the paired-pulse ratio (PPR), which is the ratio of the amplitude of the second response to that of the first, depends on the probability of vesicular release at the synapse, and PPR has been used as an easy measure of the release probability.
What is paired pulse stimulation?
Paired-pulse stimulation is a standard protocol that has been used for decades to characterize dynamic systems: the differences in responses to two sequential identical stimuli as a function of inter-stimulus interval provide quantitative information on the dynamics of the system.
What does paired pulse facilitation mean?
Paired-pulse facilitation (PPF) is a form of short-term, activity-dependent synaptic plasticity common to most chemically transmitting synapses, manifested as an enhancement in the amplitude of the second of two rapidly evoked excitatory postsynaptic potentials (EPSPs).
What is paired pulse depression?
Paired pulse depression (PPD) is a common form of short-term synaptic plasticity. The aim of this study was to characterise PPD at the level of a single inhibitory bouton. It coincided with paired pulse depression of the presynaptic Ca2+ transients (τ = 120 ms).
How is paired pulse ratio measured?
A widely used method of calculating the PPR is to take the mean of the ratios of responses to pairs of stimuli, A2/A1 [i.e., mean(A2/A1)]. If PPR > 1, an increase in the probability of transmitter release is said to have occurred.
How do you find a paired pulse ratio?
Computer simulations. A widely used method of calculating the PPR is to take the mean of the ratios of responses to pairs of stimuli, A2/A1 [i.e., mean(A2/A1)]. If PPR > 1, an increase in the probability of transmitter release is said to have occurred.
What is paired pulse inhibition?
Prepulse inhibition (PPI) is a neurological phenomenon in which a weaker prestimulus (prepulse) inhibits the reaction of an organism to a subsequent strong reflex-eliciting stimulus (pulse), often using the startle reflex. PPI is detected in numerous species including mice and humans.
Is paired pulse facilitation presynaptic?
Summary. Paired-pulse facilitation (PPF) of excitatory synaptic transmission at Schaffer collateral synapses in the hippocampus was examined in relationship to long-term potentiation (LTP). PPF is a relatively simple-to-measure presynaptic form of synaptic plasticity.
What is meant by postsynaptic?
Definition of postsynaptic 1 : occurring after synapsis a postsynaptic chromosome. 2 : of, occurring in, or being a nerve cell by which a wave of excitation is conveyed away from a synapse a postsynaptic membrane.
How does postsynaptic receptor population change during paired pulse stimulation?
The postsynaptic receptor population should not have time to change during a paired pulse stimulation and if the treatment causes an effect by binding to the post-synaptic receptors, then the PPR should remain stable.
Is paired-pulse ratio related to release probability at hippocampal CA1 synapses?
Paired-pulse ratio of synaptically induced transporter currents at hippocampal CA1 synapses is not related to release probability When a synapse is stimulated in rapid succession, the second post-synaptic response can be larger than the first and termed paired-pulse facilitation.
What is paired-pulse ratio (PPR)?
It has been reported that the paired-pulse ratio (PPR), which is the ratio of the amplitude of the second response to that of the first, depends on the probability of vesicular release at the synapse, and PPR has been used as an easy measure of the release probability.
When a synapse is stimulated in rapid succession the second response?
When a synapse is stimulated in rapid succession, the second post-synaptic response can be larger than the first and termed paired-pulse facilitation. It has been reported that the paired-pulse ratio (PPR), which is the ratio of the amplitude of the second response to that of the first, depends on t …