What is endometrium with tubal metaplasia?
Definition: Tubal metaplasia of the endometrium refers to the presence of large number of tubal-type ciliated cells in the endometrial mucosa. It is usually an incidental finding but is seen more commonly in association with endometrial hyperplasia. It may result in abnormal cells in a Pap smear.
Is Tubal metaplasia normal?
Although atypical tubal metaplasia is presumed to be reactive or degenerative in etiology, its clinical significance is unknown.
What does secretory endometrium on endometrial biopsy mean?
After ovulation occurs, the endometrium enters the luteal or secretory phase, which means that the lining has undergone a series of changes which will prepare it for a possible pregnancy. If pregnancy does not occur, the thickened endometrium will be shed during menstruation.
Is Tubal metaplasia precancerous?
It is generally known that endometrial tubal metaplasia is a benign disease. However studies propose endometrial tubal metaplasia to be a potential premalignant endometrial lesion and its association with endometrial hyperplasia and well-differentiated endometrioid carcinoma.
What is ciliated tubal metaplasia?
It refers to the presence of large number of tubal-type ciliated cells in the endometrial mucosa. It is usually an incidental finding but is seen more commonly in association with endometrial hyperplasia. It may result in abnormal cells in a Pap smear.
What causes tubal metaplasia?
Endometrial tubal metaplasia (ETM) is mostly described in conjunction with unopposed estrogen levels, and its association with endometrial hyperplasia and endometrial carcinoma (EC) is striking. Obesity is a risk factor for endometrial hyperplasia and EC development.
How long does the secretory phase last?
about 13 days
The secretory phase typically lasts about 13 days. Menstruation occurs in cycles. The ovaries prepare an egg (oocyte) for release and the womb (uterus) prepares a lining to nourish the egg if it is fertilised.
What triggers metaplasia?
Metaplasia is the replacement of one differentiated somatic cell type with another differentiated somatic cell type in the same tissue. Typically, metaplasia is triggered by environmental stimuli, which may act in concert with the deleterious effects of microorganisms and inflammation.
What is cervical metaplasia?
Squamous metaplasia in the cervix refers to the physiological replacement of the everted columnar epithelium on the ectocervix by a newly formed squamous epithelium from the subcolumnar reserve cells. The region of the cervix where squamous metaplasia occurs is referred to as the transformation zone.
What is secretory metaplasia in endometrium?
Secretory Metaplasia in Endometrium is a type of metaplasia noted in the uterine corpus. It is diagnosed by a pathologist on examination of endometrial tissue under a microscope. What are the other Names for this Condition? (Also known as/Synonyms) What is Secretory Metaplasia in Endometrium? (Definition/Background Information)
What is Tubal metaplasia of endocervix?
Tubal metaplasia: a cytologic study with comparison to other neoplastic and non-neoplastic conditions of the endocervix Tubal metaplasia of the endocervix (TME), a condition that may be confused morphologically with glandular neoplasia, is frequently found in cone or hysterectomy specimens.
What is endometrial ciliated metaplasia?
Endometrial ciliated and tubal metaplasia Ciliation is a characteristic feature of Müllerian epithelia, and its ubiquitous presence in the cervix, isthmus and normal proliferative endometrium could suggest that lesions exhibiting a predominant ciliated component do not represent a true metaplasia but rather a hyperplasia of ciliated cells.
Is there cytologic atypia in endometrial metaplasia?
Comment: There are foci with cytologic atypia that exceed the allowable spectrum of atypical changes seen in endometrial metaplasia. Therefore, the findings are most consistent with atypical endometrial hyperplasia.