Who invented the first antidepressant?
Klaus Schmiegel (born June 28, 1939), is most famous for his work in organic chemistry, which led to the invention of Prozac, a widely used antidepressant….
| Klaus Schmiegel | |
|---|---|
| Alma mater | University of Michigan Dartmouth College Stanford University |
| Known for | Inventing fluoxetine, the active ingredient in Prozac |
Who invented fluoxetine?
Eli Lilly and CompanyFluoxetine / Inventor
In 1988 the pharmaceutical firm Eli Lilly and Company introduced Prozac (fluoxetine), a new type of antidepressant that was safer and more effective than those of previous eras. The development of this groundbreaking drug was undertaken by three Eli Lilly researchers: Ray Fuller, David Wong, and Bryan Molloy.
Who invented citalopram?
Citalopram was first synthesized in 1972 by chemist Klaus Bøgesø and his research group at the pharmaceutical company Lundbeck and was first marketed in 1989 in Denmark.
When was fluoxetine invented?
Fluoxetine was approved by the FDA in December of 1987 and was launched to the market in January 1988 under the trade name Prozac® (for an excellence review on the development of fluoxetine see Wong, Bymaster, & Engleman, 1995; Wong, Perry, & Bymaster, 2005).
How were antidepressants first discovered?
The history of antidepressants began, by chance, in the 1950s. Chemists developing a new treatment for tuberculosis tested the drug iproniazid on patients at Seaview Hospital on Staten Island. It was a crucial step in the history of depression treatment, as these patients experienced a dramatic change in well-being.
What are the oldest antidepressants?
Tricyclic antidepressants affect three brain chemicals. They are serotonin, norepinephrine, and dopamine. This is one of the oldest types of antidepressants.
When were SSRIs first introduced?
SSRIs were introduced in the 1980s, and shortly thereafter they became some of the most commonly used antidepressants, primarily because they have fewer side effects than tricyclics or MAOIs. SSRIs include fluoxetine (Prozac), paroxetine (Paxil), and sertraline (Zoloft).
What was fluoxetine originally used for?
Prozac, trade name of fluoxetine hydrochloride, first of the class of antidepressant medications called selective serotonin reuptake inhibitors (SSRIs). It was introduced by Eli Lilly pharmaceutical company as a treatment for clinical depression in 1986.
How many years of research did it take before Prozac was on the market?
After the initial publications, it took more than 16 years — during which time many challenges arose — to complete the development of fluoxetine hydrochloride (Prozac; Eli Lilly), which culminated in its approval for the treatment of depression by the US FDA on 29 December 1987.
What is the history of the drug zimelidine?
Zimelidine was developed in the late 1970s and early 1980s by Arvid Carlsson, who was then working for the Swedish company Astra AB. It was discovered following a search for drugs with structures similar to brompheniramine (it is a derivative of brompheniramine), an antihistamine with antidepressant activity.
Is zimelidine a pyridylallylamine?
Zimelidine ( INN, BAN) (brand names Zimeldine, Normud, Zelmid) was one of the first selective serotonin reuptake inhibitor (SSRI) antidepressants to be marketed. It is a pyridylallylamine, and is structurally different from other antidepressants.
How safe is zimelidine?
While zimelidine had a very favorable safety profile, within a year and a half of its introduction, rare case reports of Guillain–Barré syndrome emerged that appeared to be caused by the drug, prompting its manufacturer to withdraw it from the market.
How effective is zimelidine for cataplexy?
Zimelidine was reported by Montplaisir and Godbout to be very effective for cataplexy in 1986, back when this was usually controlled by tricyclic antidepressants, which often had anticholinergic effects. Zimelidine was able to improve cataplexy without causing daytime sleepiness.