What does the SLCO1B1 gene do?
The SLCO1B1 gene provides instructions for making a protein called organic anion transporting polypeptide 1B1, or OATP1B1. This protein is found in liver cells; it transports compounds from the blood into the liver so that they can be cleared from the body.
What is SLCO1B1 decreased function?
Having SLCO1B1 decreased function means that you may have reduced transport of certain medications into the liver for processing and removal from the body. This may lead to slightly higher than normal medication levels in the body, or have no noticeable effects.
What are SLCO1B1 drugs?
SLCO1B1 (solute carrier organic anion transporter family member 1B1) is a drug transporter that helps the body get rid of certain medicines through the liver.
What do anti statins do?
Statins help lower low-density lipoprotein (LDL) cholesterol, also known as “bad” cholesterol, in the blood. They draw cholesterol out of plaque and stabilize plaque, Blaha says.
What does OATP1B1 stand for?
OATP1B1
| Acronym | Definition |
|---|---|
| OATP1B1 | Organic Anion Transport Proteins 1b1 (transporter) |
Do statins cause muscle wasting?
Statins are commonly prescribed and successful lipid-lowering medications that reduce the risks associated with cardiovascular disease. The side effects most commonly associated with statin use involve muscle cramping, soreness, fatigue, weakness, and, in rare cases, rapid muscle breakdown that can lead to death.
Does CoQ10 help with statin side effects?
Taking CoQ10 supplements can help increase your CoQ10 levels and may reduce statin side effects. Study results of the benefits of CoQ10 for reducing muscle pain associated with statin use are conflicting, however.
Why do doctors push statins drugs?
For drug therapy, statins remain the first-line of defense for patients who are at high risk for a cardiovascular event. There are four general categories recommended to determine who is at high risk for a cardiovascular event, such as a heart attack or stroke.
Do statins make you age faster?
Summary: Not only do statins extend lives by lowering cholesterol levels and reducing the risks of cardiovascular disease, but new research suggests that they may extend lifespans as well. Specifically, statins may reduce the rate at which telomeres shorten, a key factor in the natural aging process.
What does The SLCO1B1 gene do?
Learn more The SLCO1B1 gene provides instructions for making a protein called organic anion transporting polypeptide 1B1, or OATP1B1. This protein is found in liver cells; it transports compounds from the blood into the liver so that they can be cleared from the body.
What is the distribution of SLCO1B1 variants?
Functionally significant variants of SLCO1B1 are widely distributed and occur at high frequencies around the world. SLCO1B1 diversity is greater within than between populations, and genetic variation in SLCO1B1 is generally similar to that observed for other autosomal markers.
What is the CPT code for SLCO1B1 genotyping?
SLCO1B1 genotyping may also be useful in confirming the presence of variant genotypes that affect the metabolism of SLCO1B1 transported drugs. The CPT code for SLCO1B1 testing is 81328 (provided for your guidance only). Click here to order testing supplies or call Client Services at 800-837-8362.
What is slco1b1-simvastatin?
SLCO1B1 -Simvastatin—Beyond drug-metabolizing gene products (e.g., CYP2C19, CYP2D6, TPMT, etc.), drug transporters as products of PK pharmacogenes also affect drug response. 33 The gene SLCO1B1 codes for the influx (uptake) transporter organic anion transporter 1B1 (OATP1B1, also called SLCO1B1).