What does a high interleukin-2 mean?
The interleukin-2 receptor is a heterotrimeric transmembrane protein that is upregulated on activated T cells, and high sIL-2r levels are found in hemophagocytic syndromes, lymphoma, autoimmune lymphoproliferative syndrome, and other conditions associated with T-cell activation.
Does Th2 produce IL-2?
The T cell growth factor, IL-2, is the major cytokine that is produced during the primary response of Th cells. Upon differentiation into one of the two types of Th effector cells, Th1 and Th2, IL-2 production declines and is replaced by production of Th1-like (IFN-γ) or Th2-like (IL-4) cytokines.
What is the role of interleukin-2?
Interleukin-2 is made by a type of T lymphocyte. It increases the growth and activity of other T lymphocytes and B lymphocytes, and affects the development of the immune system.
What is IL-2 and what is its role in immunity?
IL-2 has an immunoregulatory role; it promotes the growth and development of peripheral immune cells in the initiation of the (defensive) immune response, and keeps them alive as effector cells. However, later in the response it has a pro-apoptotic effect.
What autoimmune diseases does high levels interleukin 2 receptor effect soluble serum?
High plasma levels of sIL-2Rα have been associated with autoimmune diseases, including Crohn disease,8 rheumatoid arthritis,9 and multiple sclerosis10 and higher levels have been observed in patients with coronary artery disease.
What is interleukin 2 receptor CD25 soluble?
The soluble interleukin-2 receptor (sIL-2R, sIL2R, sTAC, sCD25) is a reliable biomarker for disease activity in inflammatory disorders such as sarcoidosis.
What is IL-2 produced by?
activated T cells
As IL-2 is mainly produced by activated T cells and, in particular, by activated CD4+ T-helper cells, at least part of their ‘helper’ function for CD8+ T cells was attributed to IL-2 (Keene & Forman, 1982).
What are the side effects of interleukin 2?
Side effects of IL-2 can include flu-like symptoms such as chills, fever, fatigue, and confusion. Some have nausea, vomiting, or diarrhea. Many people develop low blood pressure, which can be treated with other medicines.
Is IL-2 inflammatory?
IL- 2 promotes inflammatory responses through the generation of Th1 and Th2 effector cells. IL-2 also blocks the differentiation of T cells into Th17 effectors and promotes the development or the maintenance of peripheral Tregs.
Is IL-2 a growth factor?
Based primarily on vitro studies, interleukin (IL)-2 has been considered a key growth and death factor for antigen-activated T lymphocytes. IL-2 is also essential to maintain self-tolerance, as IL-2- and IL-2 receptor-deficient mice exhibit lethal autoimmunity.
What is soluble interleukin?
What is interinterleukin 2 (IL2)?
Interleukin-2 (IL-2) is an α-helical cytokine belonging to T-helper cell type 1. It has a molecular weight of 15kDa. The IL2 gene is mapped to human chromosome 4q27. IL-2 is originally called as T cell growth factor.
What is the IL2 gene?
The IL2 gene is mapped to human chromosome 4q27. IL-2 is originally called as T cell growth factor. to study its ability to stimulate lymphocyte growth and prevent apoptosis as an antigen in enzyme-linked immunosorbent assay (ELISA), to analyse the human autoantibody reactivities in health and in type 1 diabetes mellitus
What is the cost and availability of interleukin-2 (hil-2)?
Pricing and availability is not currently available. Recombinant Interleukin-2, human (hIL-2) is produced in E. coli and purified by standard chromatographic techniques. Solution in PBS and 1 mg/ml BSA, filtered through a 0.2 μm pore size membrane. Species specificity: Recombinant IL-2, human is effective on mouse and human cells.
What is the molecular mass of human interleukin 2?
The peak corresponds to the calculated molecular mass of 15400 Da. Recombinant human IL-2 (interleukin 2) stimulates growth and differentiation of cells of the lymphoid lineage, such as T, NK, and B cells. IL-2 is a potent immunomodulatory cytokine, as it prevents autoimmunity and has key functions during infections.